I'm running my first game of Dungeons and Dragons Basic tonight and I'm really thinking about making it a mash-up between a Metamorphosis Alpha style dungeon in space game and the Forgotten Realms. Magic would be partially a mutation effect brought on by deep space radiation; partially the ship's artificial intelligence getting bored with the normal human biology and experimenting to see what sort of mutations it could bring about within select populations; and partially the mystification of futuristic technologies by a now primitive human population that has created self-identified races that it now uses to determine tribal affiliations. Monsters would be humans who have mutated physically.
I'm not sure but I feel like the game would have to begin with the death of Elminster and then an explosion in the aft deck levels 34-56. Give the players lots to worry about . . .
I'm in a mood today.